Section 1044 Chuai son play, 400 college students in Henan migrant workers play [Nanjing university research on small RNA overturn the theoretical basis for genetically engineering crops breeding: food must be completely safe; seeds to cultivate crops, in security must be foolproof, and transgenic dentist technology most appropriate, perhaps the only legitimate purpose is genetic weapons! It is most suitable for molesting life, contempt for life and destroy life. Insecurity, is not genetically engineered crops, according to the most hard-breeding! No matter how precise genetic engineering, can only be ruined varieties. Transgenic rice (!, And possibly wheat) commercialized by our decision-makers to halt, turn pretty crazy comeback interest groups come - after September 20, the Chinese transgenic big stage, surging, magnificent dentist - I It seems that GM food interest groups frenzied counterattack, but a last-ditch struggle. Not surprising, nor terrible. Their golden rice bowl is broken science and the public, you can not go crazy?
MicroRNA: precision attack dentist weapons almost certain genetic researchers Elite School of Life Sciences, Nanjing University, Jiangsu MicRNA Biology and Biotechnology Research Center and other units of the discovery, the plant microRNAs (microRNA) can enter the body through the blood the way of daily food intake and tissues and organs. And, once inside the body, the way they will target the human body by regulating gene expression of the body's physiological functions, and thus play a biological role. This discovery not only enriches our understanding of RNA, while also making weapons with precision strike capability dentist gene into the structural design and project implementation phase. An attack principle picornavirus microRNA genes arms (microRNA) are a class of about 19-24 nucleotides small molecule non-coding RNA, which target gene with the messenger RNA (mRNA) corresponding to a combination of inhibition protein translation. Molecular biology of this process is that small RNA genes can be used as weapons to attack the theoretical basis and principles. dentist To make do not have the basic knowledge of molecular biology, people can better understand the principles of this attack, where we need to look at a simple universal basic knowledge about DNA, RNA and proteins. A nucleic acid multimer. It is the basic unit of a nucleotide. Nucleotide consists dentist of a ribose (pentose), a (cyclic nitrogen-containing) base and a phosphate composition. Multiple basic units together is RNA polymerization, referred to nucleic acids. Nucleic There are two types of deoxyribonucleic acid (DNA), ribonucleic acid one is (RNA). Difference between the two is: DNA in a five-carbon sugar less oxygen atom, called deoxyribose, RNA in the five-carbon sugars without losing oxygen atoms, called ribose; DNA has the nucleotide A, T, G, C four species, and the RNA bases are A, U, G, C of four, only two different T and U; DNA is double dentist stranded (double helix), RNA generally present in single-stranded form. DNA is a long double-stranded macromolecules. It's a structure like a very, very long "ladder": ladders on both sides of the long "stick" (chain) by alternating deoxyribose and phosphate connected together. Rungs of the ladder by the docking of two bases together. Base pairs to accept the "贾格夫 given the" requirement: that A can only dock with T (composed of rungs), G only with C Butt (composed of rungs). Thus, DNA will look into as shown in Figure. Compared with DNA, RNA only half of the ladder, plus the difference between ribose and base of U. The so-called gene is actually a piece of DNA. Length is generally from 800 to 1500 base pairs (ladder rungs). We already dentist know, DNA total of only four different dentist nucleotide differences, then how can carry four bases of genetic information dentist in vivo biological and a huge amount of it? This involves the DNA genetic information storage problems. Previous studies have found, DNA in three consecutive bases (eg AAG) a decision of a single chain of amino acids (such as lysine) way storage of genetic information. To this end, we used as a base for three consecutive codons, called "three-piece password." Four bases in any order, there are 64 different combinations (codons). However, the amino acid composition of proteins in nature, only 20 species, 64 kinds of codons is how the 20 amino acids corresponding to it? Previous studies showed that 64 kinds of codons, some codons can correspond to the same amino acid (synonymous codons), and UAA, UAG, UGA codon three no corresponding amino acid, but merely a transcription termination signals. Thus, the 20 amino acids and 64 kinds of codons on their places of (Table). (Figure) although rungs on the base of received 贾格夫 given the strict rules, but the entire biosphere is, DNA bases Sort vertical ladder is unrestricted, plus three consecutive bases an amino group decision, so that, although only four bases, it is still a huge amount sufficient to carry the genetic information of biological DNA. So how is the role of the gene it? The first theory is that "a genetically determined an enzyme." The so-called enzyme is a protein having a catalytic function. Thus, ultimately through gene enzyme dentist (protein) to function. However, and how the gene into the enzyme (protein)? dentist By genes into the process of protein, you first need a "transcription" of genetic information. The so-called transcription is to the single-stranded DNA codons meaningful information "transcribed" down, stored in the mRNA, the mRNA template is called messenger RNA or RNA, protein synthesis is actually equivalent to the time of construction drawings ( Figure). After transcription is complete, and then by another tRNA sequence according to the triplet code shown on the mRNA sequence dentist corresponding amino acid transport protein assembly connected to the ribosome. This process is called "translation." The whole process of gene transcription to translation of protein synthesis is called gene expression. Since codons contain different type of gene, thus, they express a protein consisting of amino acid-producing species, and sequence number is not the same, and thus the function of the protein is not the same. Be certain protein histone gene expression, protein expression of certain genes only regulate the addition of protein expression of some genes become dentist modified enzyme catalyzed biochemical reactions, dentist some only complete gene transcription, protein translation is not performed . That is the nature of gene action. We already know, mRNA is single-stranded, and if there is a period of the order of arrangement of the base opposite to the mRNA for some single-stranded RNA (antisense RNA) in the same cell, then this will be according dentist to the nucleotide antisense RNA docking principle ( where A and U are butt) attract each other and become double-stranded mRNA RNA. This change, figuratively speaking, dentist equivalent to the original mRNA is another consequence of the normal period of antisense RNA "hold", and "hold" is no longer a "translation" and completed the synthesis of proteins, which can cause subsequent a series of physiological and biochemical processes blocked. Thus, RNA is the target to attack gene "hold" the way. Of course, to make some kind of target gene RNA can complete attack missions, must also require such RNA can successfully invade the target tissue cell gene is located. Studies of Nanjing University showed that plant microRNAs may enter the body through food intake way. This tells us that the small RNA as genetic weapons, does not exist "launch" problem. Development of small RNA genes weapons without theoretical and technical obstacles. Second, design a genetic weapon. Prerequisite for the design of genetic weapons of war are often killing the country, dentist between nations. One war to destroy weapons to use them to save their own genes, gene weapons design must feature genes for other people, otherwise it will lead to terrible consequences dentist perish together. Therefore, to fully understand the characteristics of each gene sequence is a necessary dentist prerequisite dentist for genetic weapons design. Sequencing the human genome dentist has already been completed, in 2001 published the human genome and preliminary analysis dentist results. Human genomics, proteomics and gene functions have been expanded in-depth study of aspects, as determined to produce genetically weapons and weapons of war ready to launch a national gene "investigation" characterized genes from other races provided favorable conditions. Estimate genetic characteristics of different nationalities and more than perhaps is secretly seeking to study. Once the genetic characteristics of the target population to determine, with precision strike capability weapons gene can start immediately. 2. Called warhead warhead design is specific for the DNA sequence of the target gene. This sequence can be transcribed in the food requirements in some organisms dentist can effectively "hold" dentist small RNA specific mRNA target population. Warhead designed DNA sequence comprising transcription (transcription of small RNA), including promoters of other genes, including the structural member. Since only small RNA nucleotides ten to twenty, therefore, not only simple design transcribed sequences, and, can easily synthesized. On the whole "elastomer" is concerned, the choice of promoter design is also very critical, dentist it not only determines the effectiveness of transcribed sequences transcribed, but also with the tactical requirements related - such as the time the expression of genes transcribed warheads, transcription and transcriptional expression sites Expression strength. 3. Here the selection of said launch vehicle launch vehicle is not referred to as "transgenic" dentist as desired plasmid or virus, but was carried warhead means a biological, specifically, is crops, vegetables, fruits, edible biological . What should be the choice of bio as "bullet" fired tool, is implemented by the destination and the strategic and tactical decisions genes weapons of war. 4. Purpose and gene warfare strategy dentist and tactics of war, there are two genes: one is physical dentist elimination. In order to eliminate each other from the flesh, you can choose a different crop or animal eating habits according to the target population. The second is for commercial purposes. In order to obtain commercial interests, genetic weapons designed only to make the other side "onset", but also must design the appropriate "antidote" for the "cause." "Antidote" design is designed dentist for the antisense microRNAs microRNAs "Slug", and if "pathogenic" gene weapon in a crop of "launching" Tools, "antidote" is available another crop as "launch" tool can also be made directly to small RNA antisense oral agents. If you want to achieve each objective physical elimination, dentist neither genetic weapons design should follow immediately cause death, not easily detected by the principle of each other, otherwise fail to destroy each other's objectives. Not immediately cause death in two ways. First, the amount of transcription dentist of RNA as a small warhead to be just right. The purpose is to get into the body of the small RNA expression of the human body is only proper control of target genes but do not let it completely silent. Second, the target gene was not apparent on the surface after the attacks of pathogenic, but only cause such as gonadal dysgenesis, sexual maturation and other chronic obstruction, hidden physiological dysfunction, so as to allow a slow death or loss of the target population dentist for the purpose of reproductive function . In addition, dentist to make their own genetic weapons is not detected by the other party, except dentist to follow the principle of not causing death immediately outside, the promoter used to maximize the use of the promoter of the crop itself. Third, the characteristics of the gene, compared with the traditional weapons of war of war, genetic weapons of war is a new form of war, it has the following characteristics: First concealment. No gene battlefield weapons of war, no smoke, no armies confront each other, but do not need radar and early warning aircraft. Especially with the transgenic technology continues to mature, the use of transgenic vectors and gene transfer methods dentist become increasingly diverse, identification is not an organism genetically modified organisms will become increasingly difficult. War is a lie packaged into a beautiful myth, "bullets" in food quietly, "exploding", which has a strong hidden; second is powerful. Atomic power although monstrous, sprawling country who still might make some people survived, hidden in everyday foods invisible weapons are simply dentist not let your fantasies left to live after the war, because the gun easy to hide, "stab in the back "difficult to prevent; third is to prevent and deter difficult. At least at this stage, to prevent and deter gene weapons of war is very difficult, because the transgenic technology for the evils of war is not only possible in an attempt to "increase food production, food security" and "high-tech means" sacred cloak protection Security initiation, and gene weapons of war will be smooth and expeditious implementation of trade rules under the joint promotion of economic globalization and capital. In short, the human era has come to play God, science is revealing the hideous face. Time will eventually prove itself in terms of human, transgenic technology is by no means gospel, but disaster. In this sense, perhaps it is human GM food prepared for their "Last Supper."
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